Proteasomal degradation of preemptive quality control (pQC) substrates is mediated by an AIRAPL–p97 complex
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چکیده
منابع مشابه
Proteasomal degradation of preemptive quality control (pQC) substrates is mediated by an AIRAPL–p97 complex
The initial folding of secreted proteins occurs in the ER lumen, which contains specific chaperones and where posttranslational modifications may occur. Therefore lack of translocation, regardless of entry route or protein identity, is a highly toxic event, as the newly synthesized polypeptide is misfolded and can promiscuously interact with cytosolic factors. Mislocalized proteins bearing a si...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2015
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e15-02-0085